| Date | Location | Result | |
| 03/02/06 | Charleston, SC | Furman 66, Coll. of Charleston 63 | Box score |
| 02/25/06 | Statesboro, Ga. (Hanner Fieldhouse) | Georgia Southern 65, Coll. of Charleston 61 | Box score |
| 2/20/06 | Cullowhee, N.C. (Ramsey Center) | Western Carolina 98, Coll of Charleston 65 | Box score |
| 02/18/06 | John Kresse Arena | Chattanooga 68, Coll of Charleston 63 | Box score |
| 02/15/06 | Tiger Arena (Savannah, Georgia) | College of Charleston 75, Savannah State University 53 | Box score |
| 02/13/06 | John Kresse Arena | UNC Greensboro 59, Coll of Charleston 58 | Box score |
| 02/11/06 | John Kresse Arena | Elon 50, Coll of Charleston 39 | Box score |
| 02/07/06 | Greenville, SC | Furman 64, Coll of Charleston 55 | Box score |
| 02/04/06 | Spartanburg, S.C./Benjamin Johnson Arena | College of Charleston 59, Wofford 45 | Box score |
| 01/30/06 | John Kresse Arena | Davidson 71, Coll of Charleston 67 | Box score |
| 01/28/06 | John Kresse Arena | Coll of Charleston 65, Appalachian State 57 | Box score |
| 01/23/06 | John Kresse Arena | Coll of Charleston 69, Western Carolina 59 | Box score |
| 01/21/06 | Chattanooga, Tenn. (The McKenzie Arena) | Chattanooga 89, College of Charleston 41 | Box score |
| 01/18/06 | John Kresse Arena | Coll of Charleston 72, Anderson 71 | Box score |
| 01/16/06 | Greensboro,NC (Fleming Gym) | College of Charleston 70, UNC Greensboro 67 | Box score |
| 01/14/06 | Elon, N.C. (Alumni Gym) | Elon 65, Col. of Charleston 44 | Box score |
| 01/09/06 | John Kresse Arena | Coll of Charleston 52, Furman 50 | Box score |
| 01/07/06 | John Kresse Arena | Coll of Charleston 59, Wofford 50 | Box score |
| 01/03/06 | Belk Arena (Davidson, N.C.) | Davidson 71, College of Charleston 57 | Box score |
| 12/31/05 | Carmichael Auditorium, Chapel Hill | North Carolina 101, College of Charleston 48 | Box score |
| 12/20/05 | Myrtle Beach, SC (MB Convention Center) | Coastal Carolina 58, College of Charleston 51 | Box score |
| 12/15/05 | Boone, N.C. (Holmes Center) | Appalachian State 76, COFC 62 | Box score |
| 12/07/05 | John Kresse Arena | East Tennessee State 59, Coll of Charleston 55 | Box score |
| 12/05/05 | John Kresse Arena | Coll of Charleston 54, Stetson 47 | Box score |
| 12/03/05 | John Kresse Arena | Coll of Charleston 79, Georgia Southern 66 | Box score |
| 11/23/05 | Alexander Memorial Coliseum | Georgia Tech 66, College of Charleston 50 | Box score |
| 11/21/05 | Morehead, Ky. | Morehead State 66, College of Charleston 50 | Box score |
| 11/18/05 | North Charleston Coliseum | Coll. of Charleston 69, Charleston Southern 56 | Box score |